Oddsson E, Binder V, Thorgeirsson T, Jónasson T A, Gunnlaugsson O, Wulff M, Jónasson K, Wulff H R, Bjarnason O, Riis P
Scand J Gastroenterol. 1977;12(6):689-94. doi: 10.3109/00365527709181705.
Iceland (IS) and Denmark (DK) are ethnically, culturally, and economically closely related Nordic countries, but gastric cancer is much more frequent in Iceland, and other differences in the occurrence rates of gastric diseases are also suspected. Therefore a cooperative study was initiated comparing Icelandic and Danish patients with gastric ulcer (GU), duodenal ulcer (DU), and X-ray negative dyspepsia (XND) as regards clinical features, external factors of possible importance for gastritis and cancer, gastroscopic appearance, and histological gastric mucosal changes. The project lasted one year and comprised 93 Icelandic and 88 Danish patients. A large number of comparisons showed a high degree of similarity between Icelandic and Danish patients. Significant differences were found in tobacco consumption (DK greater than IS), duration of symptoms in XND (IS greater than DK), whereas the positon ratio of GU (IS less than DK) and acetylsalicylic acid consumption (DK greater than IS) showed non-significant trends. Significant difference was found between the occurrence of diffuse macroscopic changes of the gastric mucosa (IS greater than DK), which corresponds to the histological differences to be described in a subsequent article.
冰岛（IS）和丹麦（DK）是在种族、文化和经济上紧密相关的北欧国家，但胃癌在冰岛更为常见，人们还怀疑胃病发病率存在其他差异。因此，开展了一项合作研究，比较冰岛和丹麦患胃溃疡（GU）、十二指肠溃疡（DU）和X线阴性消化不良（XND）的患者在临床特征、可能对胃炎和癌症有重要影响的外部因素、胃镜表现以及胃黏膜组织学变化等方面的情况。该项目持续了一年，包括93名冰岛患者和88名丹麦患者。大量比较显示冰岛患者和丹麦患者之间有高度相似性。发现吸烟量（丹麦大于冰岛）、XND患者症状持续时间（冰岛大于丹麦）存在显著差异，而GU的位置比例（冰岛小于丹麦）和阿司匹林摄入量（丹麦大于冰岛）呈现非显著趋势。胃黏膜弥漫性宏观变化的发生率存在显著差异（冰岛大于丹麦），这与后续文章中描述的组织学差异相符。
