Friman C, Juvani M, Skrifvars B
Scand J Rheumatol. 1977;6(3):177-82. doi: 10.3109/03009747709095445.
The glycosaminoglycans (GAG) directly adsorbable from undiluted plasma on DE-52 anion-exchange cellulose (free GAG) and the GAG adsorbable on AG 1 X 2 anion exchange resin after papain proteolysis (bound GAG) were determined in 35 patients suffering from active erosive rheumatoid arthritis (RA) and in 50 control subjects. Free GAG levels were significantly elevated in both female (p less than 0.001) and male (p less than 0.05) RA patients. Bound GAG levels were significantly depressed in female (p less than 0.02) but not in male RA patients. Total GAG concentrations in RA patients and in controls were fairly similar. No consistent differences in the electrophoretic patterns of the plasma GAG from RA patients and controls were discernible. The free GAG concentrations in RA plasma samples did not correlate with seropositivity or ESR.
在35例活动性侵蚀性类风湿性关节炎（RA）患者和50例对照受试者中，测定了可从未稀释血浆直接吸附于DE - 52阴离子交换纤维素上的糖胺聚糖（GAG，游离GAG）以及木瓜蛋白酶蛋白水解后可吸附于AG 1 X 2阴离子交换树脂上的GAG（结合GAG）。在女性（p<0.001）和男性（p<0.05）RA患者中，游离GAG水平均显著升高。在女性RA患者中，结合GAG水平显著降低（p<0.02），但在男性RA患者中无此现象。RA患者和对照受试者的总GAG浓度相当相似。RA患者和对照受试者血浆GAG的电泳图谱没有一致的差异。RA血浆样本中的游离GAG浓度与血清阳性或血沉无关。
