Burger D H, Kappetein A P, Boutkan H, Breslau P J
Department of Surgery, Rode Kruis Ziekenhuis, The Hague, The Netherlands.
J Am Coll Surg. 1997 Sep;185(3):234-6.
Postoperative urinary retention is a common complication after surgical procedures. It can cause bladder dilatation, infection, and even sepsis. Carbachol/diazepam and alfusozine have been reported to lower the incidence of postoperative urinary retention, but no study showed the benefits of these drugs in a randomized, placebo-controlled trial.
We used a double blind, placebo-controlled trial in which 249 patients with postoperative urinary retention were randomly assigned to receive carbachol/diazepam (n = 72), alfusozine (n = 82), or placebo (n = 95). The primary endpoint was miction within 2 hours after taking the medication.
There was no significant difference in miction frequency after taking the medication among the three groups (p = 0.31). The miction rate was 60% for patients in the alfusozine group, 61% in the carbachol/diazepam group, and 51% in the placebo group.
Alfusozine and carbachol/diazepam had no apparent benefit on the incidence of postoperative urinary retention.
术后尿潴留是外科手术后常见的并发症。它可导致膀胱扩张、感染，甚至败血症。据报道，卡巴胆碱/地西泮和阿夫唑嗪可降低术后尿潴留的发生率，但尚无研究在随机、安慰剂对照试验中证明这些药物的益处。
我们采用双盲、安慰剂对照试验，将249例术后尿潴留患者随机分为三组，分别接受卡巴胆碱/地西泮（n = 72）、阿夫唑嗪（n = 82）或安慰剂（n = 95）治疗。主要终点是服药后2小时内排尿。
三组患者服药后的排尿频率无显著差异（p = 0.31）。阿夫唑嗪组患者的排尿率为60%，卡巴胆碱/地西泮组为61%，安慰剂组为51%。
阿夫唑嗪和卡巴胆碱/地西泮对术后尿潴留的发生率无明显益处。
