Dernell W S, Withrow S J, Straw R C, Lafferty M H
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
In Vivo. 1997 Jul-Aug;11(4):345-50.
BACKGROUND-MATERIALS: Based on previous polymer release experience, this study was conducted to evaluate the toxicity, efficacy and systemic absorption of cisplatin administered subcutaneously in dogs. METHODS-RESULTS-CONCLUSIONS: Fifty to 70 mg/m2 cisplatin was suspended in saline and injected subcutaneously in 6 dogs as an adjunct to their primary treatment for sarcoma. Gastrointestinal, bone marrow, renal or local tissue toxicity occurred following the first (dogs 1-3,5,6) and second (dogs 1 and 2) treatments. Low, yet measurable levels of platinum were present in serum through day 14 following injection in all dogs. Due to the toxicity seen, all further planned treatments were discontinued and adjuvant regimes were completed with intravenous carboplatin. Although slow systemic absorption of platinum can occur following subcutaneous administration, the degree of toxicity seen following this treatment would indicate that a drug delivery vehicle may be necessary if cisplatin is to be administered for sustained release and adsorption.
基于先前的聚合物释放经验，开展本研究以评估顺铂皮下注射给犬后的毒性、疗效及全身吸收情况。方法-结果-结论：将50至70mg/m²顺铂悬浮于盐水中，给6只犬皮下注射，作为其肉瘤主要治疗的辅助治疗。在首次（犬1 - 3、5、6）和第二次（犬1和2）治疗后出现了胃肠道、骨髓、肾脏或局部组织毒性。在所有犬注射后第14天，血清中仍存在低水平但可测量的铂。由于观察到毒性，所有进一步计划的治疗均停止，辅助治疗改用静脉注射卡铂完成。尽管皮下给药后铂可发生缓慢的全身吸收，但该治疗后观察到的毒性程度表明，如果要给予顺铂进行缓释和吸附，可能需要一种药物递送载体。
