Fries J F, Ramey D R
Department of Medicine, Stanford University School of Medicine, CA, USA.
J Rheumatol. 1997 Sep;24(9):1697-702.
Quality-of-life assessment is receiving increased attention as an outcome measure in rheumatoid arthritis (RA). The most widely used instruments use variations on a vertical visual analog scale (VAS). Since the Health Assessment Questionnaire (HAQ), Arthritis Impact Measurement Scales (AIMS), and other instruments have long included a "global" arthritis horizontal VAS (GLOB), we studied whether these 2 approaches assess the same concept.
We studied 663 patients with RA from 4 ARAMIS (Arthritis, Rheumatism, and Aging Medical Information System) centers and had them complete, in different parts of the same HAQ, the GLOB and the Torrance "feeling thermometer" (FT).
The 2 scales were highly correlated (r = -0.676; p < 0.001). Reliability (estimated by 6 month test-retest) was 0.62 for the FT and 0.83 for the GLOB. The GLOB correlated more strongly than the FT with disability (r = 0.561 vs -0.507) and pain (0.630 vs -0.553). In stepwise regressions, pain and then disability were the dominant predictors of both GLOB and FT, followed weakly by joint count and then other variables. Patients with greater disability placed more emphasis on pain and patients with greater pain appeared to value more the contribution of disability. Change scores over 6 months between GLOB and FT correlated very well (-0.59).
"Health" and "health related quality-of-life" are nearly equivalent terms. Since large longitudinal rheumatology databases contain thousands of global health VAS values, data for longitudinal quality-of-life studies in arthritis are already available, and this dimension may readily be added to longterm outcome assessment. In patients with RA, "generic" and "disease specific" assessments yield very similar results.
生活质量评估作为类风湿关节炎(RA)的一项结局指标正受到越来越多的关注。使用最广泛的工具采用垂直视觉模拟量表(VAS)的不同变体。由于健康评估问卷(HAQ)、关节炎影响测量量表(AIMS)以及其他工具长期以来都包含一个“总体”关节炎水平VAS(GLOB),我们研究了这两种方法是否评估相同的概念。
我们研究了来自4个ARAMIS(关节炎、风湿病和衰老医学信息系统)中心的663例RA患者,并让他们在同一HAQ的不同部分完成GLOB和托伦斯“感觉温度计”(FT)。
这两个量表高度相关(r = -0.676;p < 0.001)。(通过6个月重测估计的)信度,FT为0.62,GLOB为0.83。GLOB与残疾的相关性比FT更强(r = 0.561对 -0.507),与疼痛的相关性也更强(0.630对 -0.553)。在逐步回归中,疼痛然后是残疾是GLOB和FT的主要预测因素,其次是关节计数,然后是其他变量。残疾程度较高的患者更强调疼痛,而疼痛程度较高的患者似乎更重视残疾的影响。GLOB和FT在6个月内的变化得分相关性非常好(-0.59)。
“健康”和“与健康相关的生活质量”几乎是等同的术语。由于大型纵向风湿病数据库包含数千个总体健康VAS值,关节炎纵向生活质量研究的数据已经可用,并且这一维度可以很容易地添加到长期结局评估中。在RA患者中,“通用”和“疾病特异性”评估产生非常相似的结果。