不同载脂蛋白E基因型的阿尔茨海默病患者颞叶皮质中的烟碱受体、毒蕈碱受体和胆碱乙酰转移酶活性

Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes.

作者信息

Svensson A L, Warpman U, Hellström-Lindahl E, Bogdanovic N, Lannfelt L, Nordberg A

机构信息

Department of Clinical Neuroscience and Family Medicine, Karolinska Institutet, Huddinge University Hospital, Sweden.

出版信息

Neurosci Lett. 1997 Aug 22;232(1):37-40. doi: 10.1016/s0304-3940(97)00573-9.

DOI:10.1016/s0304-3940(97)00573-9

PMID:9292886

Abstract

The number of nicotinic and muscarinic receptors and choline acetyltransferase (ChAT) activity were investigated in the temporal cortex of patients with Alzheimer's disease (AD) with different apolipoprotein E (APOE) genotypes. A significant reduction in the ChAT activity (P < 0.001) and in the number of nicotinic receptors (P < 0.001) was observed in the temporal cortex of AD brains independent of APOE genotype. The number of muscarinic receptors were unchanged in AD brains compared to control in both epsilon 4 and epsilon 3 carriers. A significant negative correlation (P < 0.001) was observed in AD brains between the histopathological dementia score and ChAT activity, which was independent of the APOE genotype. In this study the presence of the APOE epsilon 4 allele was not related to specific deficits in cholinergic activity in the temporal cortex of AD brains.

摘要

在患有阿尔茨海默病（AD）且载脂蛋白E（APOE）基因型不同的患者颞叶皮质中，研究了烟碱型和毒蕈碱型受体的数量以及胆碱乙酰转移酶（ChAT）活性。在AD脑的颞叶皮质中，观察到ChAT活性（P<0.001）和烟碱型受体数量（P<0.001）显著降低，且与APOE基因型无关。在ε4和ε3携带者中，与对照组相比，AD脑中毒蕈碱型受体数量未发生变化。在AD脑中，组织病理学痴呆评分与ChAT活性之间存在显著负相关（P<0.001），且与APOE基因型无关。在本研究中，APOEε4等位基因的存在与AD脑颞叶皮质胆碱能活性的特定缺陷无关。