携带载脂蛋白ε4等位基因的阿尔茨海默病患者额叶皮质中胆碱乙酰转移酶严重缺失。
A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele.
作者信息
Soininen H, Kosunen O, Helisalmi S, Mannermaa A, Paljärvi L, Talasniemi S, Ryynänen M, Riekkinen P
机构信息
Department of Neurology, University of Kuopio, Finland.
出版信息
Neurosci Lett. 1995 Mar 3;187(2):79-82. doi: 10.1016/0304-3940(95)11343-6.
We measured the activities of choline acetyltransferase (ChAT) in the post mortem frontal cortex in 32 Alzheimer's disease (AD) patients with different apolipoprotein E (apoE) genotypes. The ChAT values were significantly lower for the AD patients with 2 epsilon 4 alleles than for those with 0 epsilon 4 (ANOVA, P < 0.05). The ChAT activities of AD patients carrying 2 or 1 epsilon 4 alleles and those without the epsilon 4 allele also differed significantly: 16.3 +/- 15.2 versus 30.5 +/- 20.6 pmol/mg protein per min, ANOVA, P < 0.05. However, the AD patients carrying the epsilon 4 allele were significantly younger than those with 0 epsilon 4 allele. The study indicates that AD patients carrying the epsilon 4 allele have a more severe cholinergic deficit than the AD patients without the epsilon 4 allele.
我们检测了32例不同载脂蛋白E（apoE）基因型的阿尔茨海默病（AD）患者死后额叶皮质中胆碱乙酰转移酶（ChAT）的活性。携带2个ε4等位基因的AD患者的ChAT值显著低于携带0个ε4等位基因的患者（方差分析，P<0.05）。携带2个或1个ε4等位基因的AD患者与不携带ε4等位基因的患者的ChAT活性也存在显著差异：分别为16.3±15.2与30.5±20.6 pmol/mg蛋白每分钟，方差分析，P<0.05。然而，携带ε4等位基因的AD患者比携带0个ε4等位基因的患者显著年轻。该研究表明，携带ε4等位基因的AD患者比不携带ε4等位基因的AD患者具有更严重的胆碱能缺陷。
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