Lewis J G, George P M, Elder P A
Steroid & Immunobiochemistry Laboratory, Canterbury Health Laboratories, Christchurch, New Zealand.
Steroids. 1997 Aug-Sep;62(8-9):632-5. doi: 10.1016/s0039-128x(97)00048-2.
Plasma androsterone/epiandrosterone sulfates, dehydroepiandrosterone sulfate, dihydrotestosterone, testosterone, androstenedione, and cortisol were measured in three normal adult men before and following finasteride administration (5 mg/day). Plasma androsterone/epiandrosterone sulfates and dihydrotestosterone declined in parallel to 50% of basal levels with little change in either dehydroepiandrosterone sulfate, cortisol, or androstenedione. The results suggest that the direct measurement of plasma androsterone/epiandrosterone sulfates by enzyme-linked immunosorbent assay provide similar information to plasma dihydrotestosterone and therefore provide a simple alternative for the assessment of 5 alpha-reductase activity.
在三名正常成年男性服用非那雄胺（5毫克/天）之前和之后，测量了血浆中的雄酮/表雄酮硫酸盐、硫酸脱氢表雄酮、双氢睾酮、睾酮、雄烯二酮和皮质醇。血浆雄酮/表雄酮硫酸盐和双氢睾酮平行下降至基础水平的50%，而硫酸脱氢表雄酮、皮质醇或雄烯二酮几乎没有变化。结果表明，通过酶联免疫吸附测定法直接测量血浆雄酮/表雄酮硫酸盐可提供与血浆双氢睾酮相似的信息，因此为评估5α-还原酶活性提供了一种简单的替代方法。
