de Lemos E R, Machado R D, Coura J R, Guimarães M A, Chagas N
Departamento de Medicina Tropical, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Rev Inst Med Trop Sao Paulo. 1996 Nov-Dec;38(6):427-30. doi: 10.1590/s0036-46651996000600007.
In order to obtain information on Brazilian spotted fever, a study in domestic animals was performed in the County of Pedreira, State of São Paulo, Brazil, where 17 human cases had been notified. Serum samples obtained from animals were tested by indirect immunofluorescence for detectable antibodies to spotted fever-group rickettsiae. Seropositivity was revealed in 12 (36.4%) of 33 dogs and seven (77.8%) of nine horses from the endemic area. For comparison, blood samples from dogs and horses from non endemic area were tested and four (12.9%) of 31 dogs and three (27.3%) of 11 horses were positive. The highest titers of antibodies by IFA (IgG > or = 1:1024) were found only in three dogs and six horses from endemic area. The results suggest that dogs as horses may serve as environmental sentinels for establishing the prevalence of foci of spotted fever in Brazil.
为获取有关巴西斑点热的信息，在巴西圣保罗州佩德雷拉县开展了一项家畜研究，该县已通报17例人类病例。对从动物身上采集的血清样本进行间接免疫荧光检测，以检测针对斑点热群立克次体的可检测抗体。来自流行地区的33只狗中有12只（36.4%）以及9匹马中有7只（77.8%）血清呈阳性。作为对照，检测了来自非流行地区的狗和马的血样，31只狗中有4只（12.9%）以及11匹马中有3只（27.3%）呈阳性。仅在来自流行地区的3只狗和6匹马中发现了IFA抗体的最高滴度（IgG≥1:1024）。结果表明，狗和马可能作为环境哨兵用于确定巴西斑点热疫源地的流行情况。
