López J M, Cárdenas I E, Campusano C, Arteaga E, Ciani S, Duarte I
Departamento de Endocrinología, Metabolismo y Nutrición, Facultad de Medicina, Pontificia Universidad Católica, Santiago de Chile.
Rev Med Chil. 1996 Nov;124(11):1315-9.
The correct management of thyroid nodules requires an accurate histological diagnosis to discard carcinoma.
To assess the diagnostic value of fine needle aspiration biopsy of thyroid nodules as compared to cytology of the same sample and surgical biopsy.
One hundred and forty three thyroid nodules were punctured with a 21 G needle under continuous aspiration obtaining a sample for cytological and histological diagnosis. Fifty patients were subjected to a thyroidectomy.
The age of studied patients ranged from 12 to 78 years old and 94% were female. Mean nodule diameter was 2.7 +/- 1.4 cm. Two percent of procedures were complicated with local hematomas, that subsided spontaneously. A diagnosis of cancer was reached in 16% of all patients and 46% of operated patients. Cytology had a 50% sensitivity, 87.5% specificity, a 89.4% positive predictive value and a 87.5% negative predictive value. The figures for fine needle aspiration biopsy were 82.6, 100, 100 and 87% respectively.
Fine needle aspiration biopsy has a better diagnostic accuracy than cytology and is a simple and safe procedure.
甲状腺结节的正确管理需要准确的组织学诊断以排除癌症。
评估甲状腺结节细针穿刺活检与同一样本的细胞学检查及手术活检相比的诊断价值。
用21G针在持续抽吸下对143个甲状腺结节进行穿刺，获取用于细胞学和组织学诊断的样本。50例患者接受了甲状腺切除术。
研究患者年龄范围为12至78岁，94%为女性。结节平均直径为2.7 +/- 1.4厘米。2%的操作并发局部血肿，血肿自行消退。所有患者中有16%、手术患者中有46%被诊断为癌症。细胞学检查的敏感性为50%，特异性为87.5%，阳性预测值为89.4%，阴性预测值为87.5%。细针穿刺活检的相应数字分别为82.6%、100%、100%和87%。
细针穿刺活检比细胞学检查具有更高的诊断准确性，且是一种简单安全的操作。
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