Tridandapani S, Kelley T, Cooney D, Pradhan M, Coggeshall K M
Ohio State University, Dept of Microbiology, Columbus 43210, USA.
Immunol Today. 1997 Sep;18(9):424-7. doi: 10.1016/s0167-5699(97)01112-2.
Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcy receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of Shc with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.
B细胞中的负向信号传导由抗原受体和Fcy受体的共交联引发，导致B细胞信号传导事件停止，进而抑制B细胞增殖和抗体分泌。在此，有人提出SHIP在阻断Shc与导致B细胞中Ras激活的蛋白质Grb2-Sos复合物相互作用方面具有竞争作用。
