Mehler P S, Schrier R W
Department of Medicine, Denver Metro Health Center, University of Colorado Health Sciences Center 80262, USA.
Kidney Blood Press Res. 1997;20(2):74-81. doi: 10.1159/000174118.
Diabetic nephropathy is the most common cause of end-stage renal disease. Diabetic patients have an increased risk of hypertension. The coexistence of diabetes and hypertension confers a high risk of morbidity to this population. Antihypertensive therapy offers an important opportunity to attenuate the rate of decline in the glomerular filtration rate and urinary albumin excretion in both insulin-dependent and non-insulin-dependent diabetic subjects. Certain calcium antagonists and converting-enzyme inhibitors are emerging as first-line agents to preserve renal function.
糖尿病肾病是终末期肾病最常见的病因。糖尿病患者患高血压的风险增加。糖尿病和高血压并存使该人群的发病风险很高。抗高血压治疗为减缓胰岛素依赖型和非胰岛素依赖型糖尿病患者的肾小球滤过率下降速度及尿白蛋白排泄率提供了重要契机。某些钙拮抗剂和转换酶抑制剂正成为保护肾功能的一线药物。
