Morhenn V B
California Skin Research Institute, San Diego 92128, USA.
Med Hypotheses. 1997 Sep;49(3):241-5. doi: 10.1016/s0306-9877(97)90209-7.
The propensity of most autoimmune diseases to manifest themselves in the skin may result from faulty teaching of what is 'self' by epithelial cells in the thymus. Whether T cells learn what is 'self' in the thymus or not until later, peripheral to the thymus, may explain the wide range of severity of autoimmune diseases. Also, I suggest that lichen planus, alopecia areata, vitiligo and psoriasis, as well as sarcoidosis and granuloma annulare are autoimmune in nature.
大多数自身免疫性疾病倾向于在皮肤中表现出来，这可能是由于胸腺中的上皮细胞对“自身”的教导有误所致。T细胞是在胸腺中就学会了什么是“自身”，还是直到胸腺外周的后期才学会，这或许可以解释自身免疫性疾病严重程度的广泛差异。此外，我认为扁平苔藓、斑秃、白癜风和银屑病，以及结节病和环状肉芽肿本质上都是自身免疫性疾病。
