[肿瘤标志物胃泌素释放肽前体（Pro-GRP）与小细胞肺癌患者预后的相关性]
[Correlation between the tumor marker Pro-GRP and prognosis in patients with small-cell lung cancer].
作者信息
Tsuchiyama T, Kawahara M, Naka N, Yamamoto S, Nakao M, Kamimori T, Okada T, Atagi S, Ogawara M, Furuse K
机构信息
Department of Internal Medicine, National Kinki Central Hospital for Chest Diseases, Osaka, Japan.
出版信息
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Jun;35(6):616-21.
We studied 90 patients with small-cell lung cancer in whom levels of Pro-GRP were abnormally high before therapy. Changes in the serum Pro-GRP level have been said to correlate strongly with therapeutic responses in patients with small-cell lung cancer. We found that changes in the serum Pro-GRP level (half-life > or = 30 vs < 30 days) were a significant prognostic factor. Multivariate analysis showed that in these patients the Pro-GRP level after therapy, Performance Status, and age were independent prognostic factors.
我们研究了90例小细胞肺癌患者，这些患者在治疗前Pro-GRP水平异常升高。血清Pro-GRP水平的变化据说与小细胞肺癌患者的治疗反应密切相关。我们发现血清Pro-GRP水平的变化（半衰期≥30天与＜30天）是一个重要的预后因素。多变量分析显示，在这些患者中，治疗后的Pro-GRP水平、体能状态和年龄是独立的预后因素。
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