局部应用丝裂霉素C成功治疗复发性角膜上皮内瘤变
Successful treatment of recurrent corneal intraepithelial neoplasia with topical mitomycin C.
作者信息
Tseng S H, Tsai Y Y, Chen F K
机构信息
Department of Ophthalmology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC.
出版信息
Cornea. 1997 Sep;16(5):595-7.
PURPOSE
To evaluate the clinical efficacy of topical mitomycin C (MMC) 0.04% in the treatment of recurrent corneal intraepithelial neoplasia.
METHODS
A 71-year-old man presented with a limbal tumor that had extended onto the inferior temporal quadrant of the left cornea. Superficial lamellar sclerokeratectomy was performed to remove the tumor, which was histopathologically demonstrated to be a corneal intraepithelial neoplasia. Fifteen months after the surgical excision, the tumor recurred at the previous keratectomy site. The patient was treated topically with 0.04% MMC four times daily for 2 weeks, during which time he only had a mild degree of conjunctival hyperemia and ocular pain.
RESULTS
The tumor resolved completely after 2 weeks of treatment and did not recur during the 10-month follow-up.
CONCLUSION
Topical MMC may be an effective alternative treatment for recurrent corneal intraepithelial neoplasia and deserves further evaluation.
目的
评估0.04%的局部用丝裂霉素C（MMC）治疗复发性角膜上皮内瘤的临床疗效。
方法
一名71岁男性患者，其角膜缘肿瘤已蔓延至左眼角膜颞下象限。进行了浅层板层巩膜角膜切除术以切除肿瘤，组织病理学检查证实为角膜上皮内瘤。手术切除15个月后，肿瘤在先前的角膜切除术部位复发。患者局部应用0.04%的MMC，每日4次，持续2周，在此期间，他仅出现轻度结膜充血和眼痛。
结果
治疗2周后肿瘤完全消退，在10个月的随访期间未复发。
结论
局部应用MMC可能是复发性角膜上皮内瘤的一种有效替代治疗方法，值得进一步评估。
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