Horta M F
Dept de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Trends Microbiol. 1997 Sep;5(9):363-6. doi: 10.1016/S0966-842X(97)01109-8.
Pore-forming proteins (PFPs) may play important roles in pathogenesis by protozoan parasites by either directly damaging the plasma membrane of the host cells or ensuring intracellular survival of the parasites by promoting their exit from lysosomal vacuoles. The Leishmania amazonensis pore-forming cytolysin, leishporin, may play a crucial role in the pathogenesis of leishmaniasis.
成孔蛋白（PFPs）可能通过直接破坏宿主细胞质膜或促进寄生虫从溶酶体空泡中逸出来确保其在细胞内存活，从而在原生动物寄生虫的发病机制中发挥重要作用。亚马逊利什曼原虫的成孔溶细胞素利什孢素可能在利什曼病的发病机制中起关键作用。
