Agostini D, Babatasi G, Scanu P, Lecluse E, Belin A, Quennelle F, Grollier G, Potier J C, Bouvard G
Service de Médecine Nucléaire, CHU Côta de Nacre, Caen.
Ann Cardiol Angeiol (Paris). 1997 May-Jun;46(5-6):293-302.
Heart failure is accompanied by major disturbances of the functioning of the sympathetic nervous system: global overactivation and local modifications of the adrenergic system. 123I-MIBG cardiac scintigraphy is an isotope technique investigating presynaptic adrenergic function. The cardiac uptake of MIBG is decreased during heart failure, reflecting a reduction of norepinephrine reuptake by cardiac presynaptic nerve endings. Alteration of presynaptic function occurs early and plays an important role in the pathogenesis of the deterioration of heart failure. 123I-MIBG cardiac scintigraphy allows in vivo assessment of the myocardial adrenergic reserves of patients with congestive heart failure. It should be proposed in all patients with severe ventricular dysfunction to help define the indications for heart transplantation.
整体过度激活以及肾上腺素能系统的局部改变。123I - MIBG心肌闪烁扫描术是一种研究突触前肾上腺素能功能的同位素技术。心力衰竭时MIBG的心脏摄取减少，反映出心脏突触前神经末梢去甲肾上腺素再摄取减少。突触前功能改变出现较早，在心力衰竭恶化的发病机制中起重要作用。123I - MIBG心肌闪烁扫描术可对充血性心力衰竭患者的心肌肾上腺素能储备进行体内评估。对于所有严重心室功能障碍的患者都应进行该项检查，以帮助确定心脏移植的适应证。
