Queneau P E, Koch S, Bresson-Hadni S, Bartholomot B, Arbez-Gindre F, Heyd B, Miguet J P
Service de Gastroentérologie, CHRU Jean Minjoz, Besançon.
Gastroenterol Clin Biol. 1997;21(6-7):511-3.
Human Fasciola hepatica infection is usually discovered either early, during the acute (invasive) phase, or in the advanced phase, which is characterized by biliary complications. We report a case of liver distomatosis with nodular intra-hepatic lesions in a 58-year-old woman. Radiological investigations showed 3 nodular lesions in the VII segment, which were difficult to distinguish from liver metastases or liver abscesses. Distomatosis serology was positive with passive hemagglutination. After a 5-day treatment with praziquantel, clinical symptoms resolved quickly while serological tests became negative. Radiological images slowly decreased to a calcified scar at 13 months. No side-effects were noted. Praziquantel, whose efficacy in the common presentations of liver distomatosis has recently been demonstrated, also seems effective and well tolerated in case of nodular intra-hepatic lesions.
人类肝片吸虫感染通常在早期、急性（侵袭性）阶段或晚期被发现，晚期以胆道并发症为特征。我们报告一例58岁女性肝吸虫病伴肝内结节性病变的病例。影像学检查显示肝VII段有3个结节性病变，难以与肝转移瘤或肝脓肿区分。肝吸虫病血清学检查被动血凝试验呈阳性。经吡喹酮治疗5天后，临床症状迅速缓解，而血清学检查转为阴性。13个月时影像学图像缓慢缩小至钙化瘢痕。未观察到副作用。最近已证明吡喹酮在肝吸虫病常见表现中的疗效，在肝内结节性病变的情况下似乎也有效且耐受性良好。
