Billé-Turc F, Padovani R, Pouget J, Serratrice G, Billé J
Service de Neurologie et Maladies neuromusculaires, CHU Timone, Marseille.
Rev Neurol (Paris). 1997 Mar;153(2):129-34.
This study, a retrospective view of 34 patients with myasthenia gravis, compared the course of the disease for patients with onset before 65 and after 65 years. 70% of those under 65 were female while 55.8% of those over 65 were male. Bulbar symptoms were more frequent in older patients. Only 3 patients had another immune disease (rheumatoid arthritis, diabetes mellitus, thyroid pathology), and two a thymoma. All patients were treated with anticholinesterases. Prednisone was used in 44% of cases and rarely Azathioprine. In our cases and in the review of the literature there is no significant difference between age groups except for the sex ratio and the outcome in the older group in case of thymoma or respiratory failure.
本研究对34例重症肌无力患者进行回顾性分析,比较了65岁之前和之后发病患者的病程。65岁以下患者中70%为女性,而65岁以上患者中55.8%为男性。延髓症状在老年患者中更为常见。只有3例患者患有另一种免疫疾病(类风湿性关节炎、糖尿病、甲状腺疾病),2例患有胸腺瘤。所有患者均接受抗胆碱酯酶治疗。44%的病例使用了泼尼松,很少使用硫唑嘌呤。在我们的病例以及文献回顾中,除了性别比例以及老年组在胸腺瘤或呼吸衰竭情况下的预后外,各年龄组之间没有显著差异。