西酞普兰在母乳中的排泄情况。
Excretion of citalopram in breast milk.
作者信息
Spigset O, Carieborg L, Ohman R, Norström A
机构信息
Division of Clinical Pharmacology, Norrland University Hospital, Umeå, Sweden.
出版信息
Br J Clin Pharmacol. 1997 Sep;44(3):295-8. doi: 10.1046/j.1365-2125.1997.t01-1-00576.x.
AIMS
The objective of this study was to measure to secretion of the selective serotonin uptake inhibitor citalopram in breast milk.
METHODS
The excretion of citalopram in breast milk was studied at steady-state conditions in two patients with depression and in one healthy volunteer after ingestion of a single dose citalopram.
RESULTS
Milk/serum concentration ratios based on single pairs of samples from the two patients ranged from 1.16 to 1.88. Based on milk concentration data from the patients, the absolute dose ingested by a suckling infant would be 4.3-17.6 micrograms kg-1 day-1, and the relative dose 0.7-5.9% of the weight-adjusted maternal dose. Based on area-under-the-time-concentration curves from the healthy volunteer, the milk/serum ratio was 1.00, the absolute dose to the infant during steady-state conditions would be 11.2 micrograms kg-1 day-1 and the relative dose 1.8% of the weight-adjusted maternal dose.
CONCLUSION
The study shows that the relative dose to a suckling infant is close to that reported for fluoxetine, and higher than reported for fluvoxamine, paroxetine and sertraline.
目的
本研究的目的是测定选择性5-羟色胺再摄取抑制剂西酞普兰在母乳中的分泌情况。
方法
在两名抑郁症患者和一名健康志愿者单次摄入西酞普兰后，在稳态条件下研究西酞普兰在母乳中的排泄情况。
结果
基于两名患者单对样本的乳/血浓度比在1.16至1.88之间。根据患者的乳汁浓度数据，哺乳婴儿摄入的绝对剂量为4.3 - 17.6微克/千克·天，相对剂量为体重调整后母亲剂量的0.7 - 5.9%。根据健康志愿者的时间-浓度曲线下面积，乳/血比为1.00，稳态条件下婴儿的绝对剂量为11.2微克/千克·天，相对剂量为体重调整后母亲剂量的1.8%。
结论
该研究表明，哺乳婴儿的相对剂量与氟西汀报道的相近，高于氟伏沙明、帕罗西汀和舍曲林报道的剂量。
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