Labbate L A, Lande R G, Jones F, Oleshansky M A
Medical University of South Carolina and VA Medical Center, Charleston 29401, USA.
Acta Psychiatr Scand. 1997 Sep;96(3):195-8. doi: 10.1111/j.1600-0447.1997.tb10151.x.
Tardive dyskinesia (TD) is a long-term potential adverse effect of neuroleptic treatment, and older age has been correlated with the development of TD. We conducted a chart review of current out-patients and examined annual Abnormal Inventory Movement Scale (AIMS) evaluations for the period 1987-1995 for 43 patients who started neuroleptic treatment after the age of 35 years. Patients (mean age 67 years) began neuroleptic treatment at a mean age of 46 years and were taking neuroleptics for 18 years on average. A total of 18 patients (42%) met the research criteria for TD, of whom all cases were mild except for three, which were moderate. Although TD was common, it rarely progressed in this naturalistic setting, suggesting that even for older patients maintenance neuroleptic treatment may be feasible for chronic psychosis.
迟发性运动障碍（TD）是抗精神病药物治疗的一种长期潜在不良反应，且年龄较大与TD的发生有关。我们对现有的门诊患者进行了病历审查，并检查了1987年至1995年期间43名35岁以后开始使用抗精神病药物治疗患者的年度异常运动量表（AIMS）评估结果。患者（平均年龄67岁）平均在46岁开始使用抗精神病药物治疗，平均服用抗精神病药物18年。共有18名患者（42%）符合TD的研究标准，其中除3例为中度外，所有病例均为轻度。虽然TD很常见，但在这种自然状态下很少进展，这表明即使对于老年患者，维持抗精神病药物治疗对于慢性精神病可能也是可行的。
