Tomitaka S I, Hashimoto K, Narita N, Minabe Y, Tamura A
Department of Cortical Function Disorder, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Brain Res. 1997 Jul 25;763(2):255-8. doi: 10.1016/s0006-8993(97)00497-6.
Using immunohistochemical technique, we investigated the regionally different roles of muscarinic receptors in the induction of HSP-70 by NMDA receptor antagonists. The administration of memantine and phencyclidine induced HSP-70 in the retrosplenial cortex of rat brain. Pretreatment with the muscarinic receptor antagonist scopolamine (0.1-1 mg/kg) blocked induction of HSP-70 in layer III of the retrosplenial cortex. However, induction of HSP-70 in layer V was augmented by scopolamine. These results suggest a regional difference in the mechanism of neurotoxicity induced by NMDA receptor antagonists.
我们运用免疫组织化学技术，研究了毒蕈碱受体在NMDA受体拮抗剂诱导HSP - 70过程中的区域差异作用。美金刚和苯环利定的给药可诱导大鼠脑压后皮质中HSP - 70的产生。用毒蕈碱受体拮抗剂东莨菪碱（0.1 - 1毫克/千克）预处理可阻断压后皮质III层中HSP - 70的诱导。然而，东莨菪碱可增强V层中HSP - 70的诱导。这些结果表明NMDA受体拮抗剂诱导的神经毒性机制存在区域差异。
