Pozharisskiĭ K M, Klimashevskiĭ V F, Gushchin V A
Tsitologiia. 1977 Jul;19(7):768-80.
Changes in proliferation of the enterocytes from the descendent colon at different developmental stages of tumours induced with 1,2-dimethylhydrazine (DMH) were studied. As a result of carcinogen-induced disturbances in enetrocyte differentiation, the proliferative crypt zone was seen broadening, the proliferative cells appearing even in the mouths of the crypts. Further, these very superficial parts of the crypts proved to be the sites of carcinoma development in situ. During the tumour induction, the majority of enterocytes display short mitotic cycles which are somewhat longer than in the normal colon. The DMH treatment, even at early stages of the experiment, leads to the appearance of a high occurrence (up to 50--60%) of abnormal mitoses in enterocytes.
研究了用1,2 - 二甲基肼（DMH）诱导的肿瘤不同发育阶段降结肠肠上皮细胞增殖的变化。由于致癌物诱导的肠上皮细胞分化紊乱，可见增殖隐窝区变宽，甚至在隐窝口也出现增殖细胞。此外，这些隐窝的非常浅表部分被证明是原位癌发生的部位。在肿瘤诱导过程中，大多数肠上皮细胞的有丝分裂周期较短，比正常结肠中的周期略长。即使在实验早期进行DMH处理，也会导致肠上皮细胞中出现高发生率（高达50 - 60%）的异常有丝分裂。
