Shashkov B V, Tsybuliak G N, Rozhdestvenskaia V O, Sviridov B E, Matveeva A I
Tsitologiia. 1977 Sep;19(9):1024-8.
Experiments were carried out on rabbits for detecting the distribution of radioactive tetanotoxin between subcellular fractions of tissues of the central nervous system. It has been found out that a parenteral administration of tetanotoxin-35S results in a quick rise of the tissue radioactivity. The radioactivity of the free ribosome fraction remained most constant and high, which might be an indication of a high acceptory capacity of these organelles to tetanotoxin. For some periods of an acute tetanus intoxication, a rather high tropism of tetanotoxin of synaptosome, microsome and myelinic fragments was found.
为检测放射性破伤风毒素在中枢神经系统组织亚细胞组分间的分布，对家兔进行了实验。已发现，肠胃外注射35S标记的破伤风毒素会使组织放射性迅速升高。游离核糖体组分的放射性保持最稳定且最高，这可能表明这些细胞器对破伤风毒素具有高接受能力。在急性破伤风中毒的某些阶段，发现破伤风毒素对突触体、微粒体和髓鞘碎片具有相当高的亲嗜性。
