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[联合照射与热疗对大鼠组织肌酸激酶活性的影响]

[Effect of combined irradiation and hyperthermia on the creatine kinase activity of rat tissues].

作者信息

Matiushichev V B, Taratukhin V R, Shamratova V G, Iuzhakova G A

出版信息

Tsitologiia. 1977 Sep;19(9):1069-71.

PMID:929696
Abstract

Effects of heating (36 degrees, relative air humidity 80-90%, 4 hours) and joint beta (85Kr)-X-ray-irradiation of rats, given separately and simultaneously, in doses 2.5 krad+ + 25 r, 2.5 krad + 50 r, 3.05 krad + 100 r, 4.45 krad + 250 r, 7.4 krad + 400 r on creatine kinase activity in brain and liver were investigated 5, 12, 19 and 26 days after the exposure. It was discovered that the state of thermal stress reduced radiosensitiveness of enzymatic activity in brain and burdened the consequences of irradiation when tested by the liver activity.

摘要

分别和同时给予大鼠加热(36摄氏度,相对空气湿度80 - 90%,4小时)及联合β(85氪)-X射线照射,剂量分别为2.5千拉德 + 25伦琴、2.5千拉德 + 50伦琴、3.05千拉德 + 100伦琴、4.45千拉德 + 250伦琴、7.4千拉德 + 400伦琴,在照射后5、12、19和26天研究其对脑和肝脏中肌酸激酶活性的影响。结果发现,热应激状态降低了脑中酶活性的放射敏感性,并在通过肝脏活性测试时加重了辐射后果。

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