Nunez J, Fischer I
Department of Neurobiology and Anatomy, Allegheny University, Philadelphia, PA 19129, USA.
J Mol Neurosci. 1997 Jun;8(3):207-22. doi: 10.1007/BF02736834.
In this article, we have described the structure and distribution of the various variants of the microtubule-associated proteins (MAPs), tau, MAP2, MAP1A, and MAP1B, that are expressed in the dorsal root ganglion (DRG) and spinal cord during development and regeneration. We have summarized the data on their gene structure and compared the sequence of the major transcripts encoding these MAPs that are expressed in the brain, the spinal cord, and the DRG. Finally, we have surveyed the studies that used a variety of experimental approaches (e.g., antisense inhibition, transgenic knockouts, and expression in neuronal and nonneuronal cells) to understand the functional significance of MAPs heterogeneity and differences observed between the central nervous system (CNS) and the peripheral nervous system (PNS) both during development and regeneration.
在本文中，我们描述了微管相关蛋白（MAPs）的各种变体，即tau、MAP2、MAP1A和MAP1B的结构与分布，这些蛋白在发育和再生过程中表达于背根神经节（DRG）和脊髓。我们总结了它们的基因结构数据，并比较了在脑、脊髓和DRG中表达的编码这些MAPs的主要转录本的序列。最后，我们综述了一系列研究，这些研究采用了多种实验方法（如反义抑制、转基因敲除以及在神经元和非神经元细胞中的表达），以了解在发育和再生过程中，MAPs异质性以及中枢神经系统（CNS）和外周神经系统（PNS）之间观察到的差异的功能意义。
