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波兰南部人群中的HLA基因及单倍型频率

HLA gene and haplotype frequencies in the population of southern Poland.

作者信息

Turowski G, Pietrzyk J J

出版信息

Arch Immunol Ther Exp (Warsz). 1979;27(4):591-600.

PMID:92977
Abstract

Results of a population study on frequencies of phenotypes and genotypes of the HLA system (locus A and B) in 240 adults, unrelated and of both sexes, living in southern Poland are reported. Frequencies of haplotypes were calculated according to Mattiuz et al. Distribution of all HLA specificities conformed with the Hardy-Weinberg law and was similar to the distribution in other white populations, except HLA-B13 which had a phenotype frequency of 14.17% and gene frequency 7%. Haplotype frequencies and positive and negative association were analogous with those in other white populations.

摘要

报告了对居住在波兰南部的240名无亲缘关系、男女皆有的成年人进行的HLA系统(A和B位点)表型和基因型频率的群体研究结果。单倍型频率根据马蒂乌兹等人的方法计算。所有HLA特异性的分布符合哈迪-温伯格定律,并且与其他白人人群的分布相似,但HLA - B13除外,其表型频率为14.17%,基因频率为7%。单倍型频率以及正负关联与其他白人人群相似。

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