Tomas J, Santafé M, Lanuza M A, Fenoll-Brunet M R
Unitat d'Histologia i Neurobiologia (UHN), Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus Tarragona Spain.
Biol Cell. 1997 Mar;89(1):19-28. doi: 10.1016/s0248-4900(99)80078-1.
The major finding of the present study is that the ultrastructural organization of the neuromuscular synapse can be modified by a small, 4-week-long, physiological increase in the locomotor activity of the extensor digitorum longus muscle of normal adult rats trained to walk. This study measures these plastic adaptations using several synaptic morphological parameters. The observed changes in neuromuscular junctions affect both pre- and postsynaptic membranes. In particular, the presynaptic membrane densities in the active zones and the postsynaptic adaxonal membrane densities become larger, which shows that in the normal adult mammal neuromuscular junction, there is an activity-dependent modulation of the neurotransmission-related structures in response to slight physiologic functional demands. The nature and magnitude of these changes are discussed.
本研究的主要发现是，通过训练正常成年大鼠行走，使其趾长伸肌的运动活性出现为期4周的小幅生理性增加，可改变神经肌肉突触的超微结构组织。本研究使用多个突触形态学参数来测量这些可塑性适应。观察到的神经肌肉接头变化同时影响突触前膜和突触后膜。特别是，活性区的突触前膜密度和突触后轴突膜密度增大，这表明在正常成年哺乳动物的神经肌肉接头中，响应轻微的生理功能需求，存在对神经传递相关结构的活性依赖性调节。文中讨论了这些变化的性质和程度。
