Schneider D, Halperin R, Langer R, Bukovsky I, Herman A
Assaf Harofeh Medical Center, Zerifin, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Gynecol Oncol. 1997 Sep;66(3):399-404. doi: 10.1006/gyno.1997.4792.
In attempt to identify patients with ovarian carcinoma and differentiate them from patients with benign ovarian tumor or other gynecological malignancies, peritoneal fluid and serum lactate dehydrogenase (LDH) levels were measured in 51 patients: 15 with ovarian carcinoma, 15 with endometrial carcinoma, 4 with cervical carcinoma, and 17 with benign ovarian tumor. Peritoneal fluid and serum LDH levels in ovarian cancer patients were significantly higher than those in patients with benign ovarian tumor (P < 0.001) or other gynecological malignancies (P < 0.001 and P < 0.03, respectively). Yet, peritoneal fluid LDH demonstrated higher diagnostic sensitivity (87%) and greater diagnostic accuracy (90%) than serum LDH (60 and 77%, respectively) or serum CA-125 (73 and 83%, respectively). Comparing the histological types of ovarian cancer, serous cystadenocarcinoma presented higher peritoneal fluid LDH levels than endometrioid or mucinous cystadenocarcinoma. No difference in peritoneal fluid LDH was observed comparing different stages of ovarian cancer. The results suggest that peritoneal fluid LDH may be an efficient biochemical marker in diagnosis of ovarian cancer.
为了鉴别卵巢癌患者，并将其与卵巢良性肿瘤或其他妇科恶性肿瘤患者区分开来，对51例患者的腹腔积液和血清乳酸脱氢酶（LDH）水平进行了检测，其中15例为卵巢癌患者，15例为子宫内膜癌患者，4例为宫颈癌患者，17例为卵巢良性肿瘤患者。卵巢癌患者的腹腔积液和血清LDH水平显著高于卵巢良性肿瘤患者（P < 0.001）或其他妇科恶性肿瘤患者（分别为P < 0.001和P < 0.03）。然而，腹腔积液LDH的诊断敏感性（87%）和诊断准确性（90%）高于血清LDH（分别为60%和77%）或血清CA - 125（分别为73%和83%）。比较卵巢癌的组织学类型，浆液性囊腺癌的腹腔积液LDH水平高于子宫内膜样癌或黏液性囊腺癌。比较不同分期的卵巢癌，未观察到腹腔积液LDH有差异。结果表明，腹腔积液LDH可能是诊断卵巢癌的一种有效生化标志物。
