Bishop D T, Kiemeney L A
ICRF Genetic Epidemiology Laboratory, St James's Hospital, Leeds, The Netherlands.
Semin Cancer Biol. 1997 Feb;8(1):45-51. doi: 10.1006/scbi.1997.0053.
Family studies of prostate cancer, in keeping with studies of many other common cancers, have shown an increased risk to relatives of cases over and above the general population. Male relatives of early onset prostate cancer cases are also at increased risk over relatives of later onset cases. These observations, together with a few families with four or more cases of prostate cancer, suggest that there is a high penetrance, inherited form of this cancer. Further evidence comes from the increased risk of prostate cancer in BRCA1 mutation carriers but more particularly from the recent report of the mapping of a prostate cancer susceptibility gene to chromosome 1.
与许多其他常见癌症的研究一致，前列腺癌的家族研究表明，病例亲属患癌风险高于普通人群。早发性前列腺癌病例的男性亲属比晚发性病例的亲属患癌风险也更高。这些观察结果，再加上一些有四例或更多前列腺癌病例的家族，表明这种癌症存在高外显率的遗传形式。进一步的证据来自BRCA1突变携带者患前列腺癌风险的增加，但更特别的是来自最近一份将前列腺癌易感基因定位到1号染色体的报告。
