Buchwald C, Franzmann M B, Jacobsen G K, Juhl B R, Lindeberg H
Department of Otolaryngology, Rigshospitalet, Copenhagen, Denmark.
Rhinology. 1997 Jun;35(2):74-8.
Carcinomas arising in pre-existing sinonasal papillomas of the nasal septum are rare. To our knowledge only one case has been reported. We report two cases of carcinomas occurring in septal papillomas. In the first case a carcinoma developed in an exophytic papilloma 16 years after the first operation for a papilloma. In the second case a carcinoma was present at the first presentation within an inverted papilloma, and a metastasis had also developed. In the first case HPV type 6/11 was demonstrated by in-situ hybridisation and PCR in the original papilloma as well as in the recurrent papilloma and in the carcinoma. In the second case HPV type 18 was found in the nasal lesion as well as in the metastasis. All samples were examined for Epstein-Barr virus (EBV) by PCR, but with negative results. We believe that case one is the first reported case of carcinomatous transformation within an exophytic septal papilloma.
鼻中隔原有的鼻窦乳头状瘤发生癌变很罕见。据我们所知，仅报道过1例。我们报告2例鼻中隔乳头状瘤发生癌变的病例。第1例，在外生性乳头状瘤第1次手术后16年发生癌变。第2例，首次就诊时倒置乳头状瘤内就存在癌变，且已发生转移。第1例，原位杂交和聚合酶链反应（PCR）在原发乳头状瘤、复发性乳头状瘤及癌组织中均检测到6/11型人乳头瘤病毒（HPV）。第2例，在鼻腔病变及转移灶中发现18型HPV。所有样本均通过PCR检测了爱泼斯坦-巴尔病毒（EBV），结果均为阴性。我们认为第1例是外生性鼻中隔乳头状瘤发生癌变的首例报道病例。
