Caffrey J F, Dudgeon A M, Donnelly W J, Sheahan B J, Atkins G J
Department of Veterinary Pathology, Faculty of Veterinary Medicine, University College Dublin, Ireland.
Res Vet Sci. 1997 May-Jun;62(3):245-8. doi: 10.1016/s0034-5288(97)90198-3.
The onset of growth retardation was investigated in fetal lambs following experimental infection of pregnant ewes with Border Disease virus (BDV) on day 53 of pregnancy. Fetuses from control and infected ewes were harvested at weekly intervals between day 60 and day 95 of gestation and morphometric studies were completed on tibial radiographs and tibial growth cartilage metaphyseal junctions. Mean tibial areas were significantly reduced (P < 0.01) in fetuses from infected ewes at 35 and 42 days after infection and growth cartilage metaphyseal junctions were less mature in fetuses from infected ewes at 42 days after infection. Positive immunostaining for BDV antigen was demonstrated in the brains of all fetuses from infected ewes between 14 and 42 days after infection. Attempts to demonstrate BDV antigen in bone proved unsuccessful. It is concluded that intrauterine growth retardation is an early manifestation of BDV infection in lambs and that the process is initiated shortly following infection of the fetus.
在妊娠第53天给怀孕母羊实验性感染边界病病毒（BDV）后，对胎羊生长迟缓的发病情况进行了研究。在妊娠第60天至第95天期间，每周对对照组和感染组母羊的胎儿进行采集，并对胫骨X线片和胫骨生长软骨干骺端连接部进行形态学研究。感染组母羊的胎儿在感染后35天和42天时，胫骨平均面积显著减小（P < 0.01），且感染组母羊的胎儿在感染后42天时，生长软骨干骺端连接部的成熟度较低。在感染后14天至42天期间，感染组母羊所有胎儿的大脑中均检测到BDV抗原的阳性免疫染色。在骨骼中检测BDV抗原的尝试未成功。得出的结论是，宫内生长迟缓是羔羊BDV感染的早期表现，且该过程在胎儿感染后不久就开始了。
