Maeda H, Ishida K, Fujita M Q
Department of Legal Medicine, Osaka City University Medical School.
Nihon Rinsho. 1997 Sep;55(9):2219-26.
Blood group antigens on the human red blood cell are originally of serological significance. Recent advances in molecular biology and genetics have greatly increased our knowledge of the chemical structures, functions, and genetic backgrounds of these antigens. Carbohydrate antigens are widely expressed in various tissues, whereas protein(polypeptide) antigens are generally specific to the surface molecules of erythroid cells, suggesting their possible roles in membrane structure and function (transporters, receptors, adhesion molecules, and enzymes). This paper reviewed the recent topics with special regard to clinical significance including blood transfusion, and discussed.
人类红细胞上的血型抗原最初具有血清学意义。分子生物学和遗传学的最新进展极大地增加了我们对这些抗原的化学结构、功能和遗传背景的了解。碳水化合物抗原在各种组织中广泛表达，而蛋白质（多肽）抗原通常对红细胞表面分子具有特异性，这表明它们在膜结构和功能（转运蛋白、受体、黏附分子和酶）中可能发挥的作用。本文特别回顾了包括输血在内的临床意义方面的近期话题并进行了讨论。
