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古菌内含子:剪接、细胞间移动性与进化

Archaeal introns: splicing, intercellular mobility and evolution.

作者信息

Lykke-Andersen J, Aagaard C, Semionenkov M, Garrett R A

机构信息

RNA Regulation Centre, University of Copenhagen, Denmark.

出版信息

Trends Biochem Sci. 1997 Sep;22(9):326-31. doi: 10.1016/s0968-0004(97)01113-4.

Abstract

Until recently, it appeared that archaeal introns were spliced by a process specific to the archaeal domain in which an endoribonuclease cuts a 'bulge-helix-bulge' motif that forms at exon-intron junctions. Recent results, however, have shown that the endoribonuclease involved in archaeal intron splicing is a homologue of two subunits of the enzyme complex that excises eukaryotic nuclear tRNA introns. Moreover, some archaeal introns encode homing enzymes that are also encoded by group I introns.

摘要

直到最近,古菌内含子似乎是通过古菌域特有的一个过程进行剪接的,在此过程中,一种内切核糖核酸酶切割在外显子-内含子连接处形成的“凸起-螺旋-凸起”基序。然而,最近的研究结果表明,参与古菌内含子剪接的内切核糖核酸酶是切除真核细胞核tRNA内含子的酶复合物两个亚基的同源物。此外,一些古菌内含子编码归巢酶,第一类内含子也编码这种酶。

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