Lawrence J C, Abraham R T
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908, USA.
Trends Biochem Sci. 1997 Sep;22(9):345-9. doi: 10.1016/s0968-0004(97)01101-8.
Insulin and growth factors elicit rapid increases in protein synthesis by stimulating mRNA translation. PHAS/4E-BPs, a recently discovered family of elF4E-binding, proteins, appear to play a key role in this process, as well as in the control of cell proliferation.
胰岛素和生长因子通过刺激mRNA翻译，使蛋白质合成迅速增加。PHAS/4E-BPs是最近发现的一类与真核翻译起始因子4E（eIF4E）结合的蛋白质，它们似乎在这一过程以及细胞增殖控制中发挥关键作用。
