Bloemendal H, Enzlin J H, Van Rijk A A, Jansen H J
Department of Biochemistry, University of Nijmegen, The Netherlands.
Exp Eye Res. 1997 Jun;64(6):1037-41. doi: 10.1006/exer.1997.0294.
Clones derived from SV40-transformed hamster lens cells have at least three different stable morphologies. Biochemical differences between the three cell types that become detectable after transfection of the alpha A-crystallin gene do exist at the level of alpha B-crystallin and small heat shock protein (HSP27) expression. Furthermore one cell type is capable of alternative splicing of the hamster alpha A-crystallin gene, whereas another one cannot express alpha AIns-crystallin.
源自SV40转化的仓鼠晶状体细胞的克隆至少有三种不同的稳定形态。在转染αA-晶状体蛋白基因后可检测到的三种细胞类型之间的生化差异确实存在于αB-晶状体蛋白和小热休克蛋白（HSP27）表达水平上。此外，一种细胞类型能够对仓鼠αA-晶状体蛋白基因进行可变剪接，而另一种则不能表达αAIns-晶状体蛋白。
