中枢给予胆碱可提高清醒大鼠的血浆催乳素水平。
Centrally administered choline increases plasma prolactin levels in conscious rats.
作者信息
Gürün M S, Savci V, Ulus I H, Kiran B K
机构信息
Department of Pharmacology, Uludag University Medical Faculty, Bursa, Turkey.
出版信息
Neurosci Lett. 1997 Aug 29;232(2):79-82. doi: 10.1016/s0304-3940(97)00580-6.
Intracerebroventricular (i.c.v.) administration of choline, a precursor of acetylcholine (ACh) increased plasma prolactin levels in a time and dose-dependent manner in conscious rats. Pretreatment of rats with the cholinergic muscarinic antagonist, atropine (10 microg, i.c.v.), blocked the increase in plasma prolactin level. The increase was not influenced by pretreatment with the cholinergic nicotinic antagonist, mecamylamine (50 microg, i.c.v.). Pretreatment with hemicholinium-3 (HC-3; 20 microg, i.c.v.), a high affinity choline uptake inhibitor, attenuated the choline-induced increase of plasma prolactin levels. These results show that choline increases plasma prolactin levels by activating muscarinic receptors via presynaptic mechanisms.
在清醒大鼠中，向脑室内（i.c.v.）注射乙酰胆碱（ACh）的前体胆碱，可使血浆催乳素水平呈时间和剂量依赖性升高。用胆碱能毒蕈碱拮抗剂阿托品（10微克，i.c.v.）预处理大鼠，可阻断血浆催乳素水平的升高。这种升高不受胆碱能烟碱拮抗剂美加明（50微克，i.c.v.）预处理的影响。用高亲和力胆碱摄取抑制剂半胱氨酸-3（HC-3；20微克，i.c.v.）预处理可减弱胆碱诱导的血浆催乳素水平升高。这些结果表明，胆碱通过突触前机制激活毒蕈碱受体来增加血浆催乳素水平。
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