Blok G J, de Boer H, Gooren L J, van der Veen E A
Department of Endocrinology, Hospital of the Vrije Universiteit, Amsterdam, The Netherlands.
Clin Endocrinol (Oxf). 1997 Jul;47(1):29-36. doi: 10.1046/j.1365-2265.1997.2021027.x.
To assess whether growth hormone (GH) administration to adult GH-deficient men leads to increased sexual hair. The sexual hair scores are subnormal in these patients, even in the presence of normal serum androgen levels.
Forty-six adult men with childhood-onset of GH deficiency of whom 25 were androgen deficient and received replacement.
Double-blind and placebo-controlled. Of the 46 patients, 33 started immediately with GH administration; the remaining 13 received placebo for the first 6 months followed by GH for the next 6 months. Sixty-one age-matched healthy men with normal height and serum concentrations of IGF-I served as a comparison group.
Hair scores at 13 defined body regions were assessed before, and after 6 and 12 months of the intervention. At the same time levels of IGF-I, dehydroepiandrosterone sulphate, androstenedione, dihydrotestosterone (DHT), testosterone and sex hormone binding globulin (SHBG) were measured. From the latter two, the free androgen index (FAI) was calculated.
Before GH administration, hair scores in the GH deficient patients were lower than in the comparison group. In the 33 men treated with GH from the beginning, there was an increase in hair scores after 6 months. The increase in hair scores was not seen during 6 months of placebo treatment. When the placebo group switched to GH administration, their hair scores had also significantly increased after 6 months of GH substitution therapy. Upon GH administration both levels of SHBG and testosterone/DHT declined while the FAI remained unchanged.
GH substitution therapy to GH deficient men has an auxiliary effect on androgen action in the skin without an increase of the FAI.
评估对成年生长激素缺乏男性使用生长激素（GH）是否会导致性毛增多。这些患者的性毛评分低于正常水平，即便其血清雄激素水平正常。
46名成年男性，童年起病的生长激素缺乏，其中25名雄激素缺乏并接受替代治疗。
双盲、安慰剂对照。46名患者中，33名立即开始使用生长激素；其余13名在前6个月接受安慰剂治疗，接下来6个月接受生长激素治疗。61名年龄匹配、身高正常且血清胰岛素样生长因子-I（IGF-I）浓度正常的健康男性作为对照组。
在干预前、干预6个月和12个月后，评估13个特定身体部位的毛发评分。同时测量IGF-I、硫酸脱氢表雄酮、雄烯二酮、双氢睾酮（DHT）、睾酮和性激素结合球蛋白（SHBG）的水平。根据后两者计算游离雄激素指数（FAI）。
在使用生长激素前，生长激素缺乏患者的毛发评分低于对照组。从一开始就接受生长激素治疗的33名男性，6个月后毛发评分增加。在接受安慰剂治疗的6个月内未观察到毛发评分增加。当安慰剂组转为使用生长激素时，在生长激素替代治疗6个月后其毛发评分也显著增加。使用生长激素后，SHBG水平和睾酮/DHT均下降，而FAI保持不变。
对生长激素缺乏男性进行生长激素替代治疗对皮肤中雄激素的作用有辅助作用，且不增加FAI。
