Wallace R W
Mol Med Today. 1997 Sep;3(9):384-9. doi: 10.1016/S1357-4310(97)01097-6.
It is expected that by the year 2003 the entire human genome will be sequenced, providing us with new insight into human disease. The amount of human sequence information that is already available (only a few percent of the total) is, however, already much greater than can be routinely evaluated with existing, commonly used diagnostic technology. New technology based on attaching DNA to a chip for parallel hybridization analysis is generating much interest in both the basic research and the clinical diagnostic community. It will increase, by orders of magnitude, our ability to evaluate an individual's genetic heritage and to conduct basic genetic research. The new technology will be a major advance in screening for genetic diseases, but the ability to treat these newly understood genetic defects will lag significantly behind the new-found diagnostic capabilities.
预计到2003年，整个人类基因组将被测序，这将为我们洞察人类疾病提供新的视角。然而，现有的人类序列信息（仅占总量的百分之几）已经远远超过了用现有的常用诊断技术所能常规评估的量。基于将DNA附着到芯片上进行平行杂交分析的新技术在基础研究和临床诊断领域都引起了极大的兴趣。它将使我们评估个体遗传特征和进行基础基因研究的能力提高几个数量级。这项新技术将在遗传疾病筛查方面取得重大进展，但治疗这些新认识到的基因缺陷的能力将远远落后于新获得的诊断能力。
