Resti M, Azzari C, Mannelli F, Rossi M E, Lionetti P, Vierucci A
Department of Pediatrics, Ospedale Meyer, University of Florence, Italy.
Vaccine. 1997 Aug-Sep;15(12-13):1338-40. doi: 10.1016/s0264-410x(97)00028-5.
One hundred and fourteen children, born to HBsAg-positive mothers received in the first year of life passive active prophylaxis for hepatitis B virus (HBV). They have been followed up to 10 years. A booster dose given in a cohort at the 5th year does not seem to increase protection against HBV. No difference in immunological memory was present at the 10th year between the group of children who had received the booster dose at 5 years of age and the group who did not.
114名母亲为乙肝表面抗原（HBsAg）阳性的儿童在出生后的第一年接受了乙肝病毒（HBV）的被动-主动预防。他们被随访至10岁。在5岁时对一组儿童给予加强剂量似乎并未增强对HBV的保护作用。在10岁时，5岁时接受加强剂量的儿童组与未接受加强剂量的儿童组之间在免疫记忆方面没有差异。
