OprM表达对铜绿假单胞菌多重耐药性的影响。
Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.
作者信息
Wong K K, Poole K, Gotoh N, Hancock R E
机构信息
Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
出版信息
Antimicrob Agents Chemother. 1997 Sep;41(9):2009-12. doi: 10.1128/AAC.41.9.2009.
Abstract
MexA-MexB-OprM is an efflux system in Pseudomonas aeruginosa. OprM overproduced from the cloned gene was able to complement OprM-deficient mutants but did not alter the resistance of a wild-type P. aeruginosa strain to the different antimicrobial agents tested. This suggests that OprM cannot function by itself to efflux antibiotics, including beta-lactams targeted to the periplasm.
摘要
MexA-MexB-OprM是铜绿假单胞菌中的一种外排系统。从克隆基因过量表达的OprM能够互补OprM缺陷型突变体，但不会改变野生型铜绿假单胞菌菌株对所测试的不同抗菌剂的抗性。这表明OprM自身无法发挥作用来外排抗生素，包括靶向周质的β-内酰胺类抗生素。
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