慢性免疫系统激活水平对体重6至112千克猪的生长及日粮赖氨酸需求的影响。

Effect of level of chronic immune system activation on the growth and dietary lysine needs of pigs fed from 6 to 112 kg.

作者信息

Williams N H, Stahly T S, Zimmerman D R

机构信息

Department of Animal Science, Iowa State University, Ames 50011, USA.

出版信息

J Anim Sci. 1997 Sep;75(9):2481-96. doi: 10.2527/1997.7592481x.

DOI:10.2527/1997.7592481x

PMID:9303467

Abstract

The effect of a low and a high level of chronic immune system (IS) activation on the rate, efficiency, and composition of body growth and dietary lysine needs of pigs fed from 6 to 112 kg body weight was evaluated. All pigs were of a single genetic strain and geographical site of origin, and the low and high IS pigs were created by physically isolating pigs from and continually exposing pigs to major vectors of environmental antigen transmission. In each IS group, five littermate barrows from each of seven litters were individually penned and randomly allotted to one of five dietary amino acid regimens (.6, .9, 1.20, 1.50, and 1.80% lysine from 6 to 27 kg BW and .45, .60, .75, .90, and 1.05% lysine from 27 to 112 kg BW). Dietary lysine concentrations were achieved by altering the ratio of corn to soybean meal in the diets, and diets were formulated such that lysine was the first-limiting amino acid. Low IS pigs possessed lower (P < .01) T lymphocyte CD4+:CD8+ ratios and serum alpha-1-acylglycoprotein concentrations. Low IS pigs also consumed more (P < .01) feed, gained body weight faster (P < .01), required less (P < .01) feed per unit of gain, and at 112 kg BW produced bodies with more (P < .12) muscle and less (P < .10) fatty tissue and offal than high IS pigs. To allow their elevated capacities for proteinaceous tissue to be expressed, low IS pigs required .15 to .30 percentage units greater dietary lysine concentrations and 2 to 5 g higher daily lysine intakes at each 14-kg BW increment from 6 to 112 kg BW.

摘要

评估了低水平和高水平的慢性免疫系统（IS）激活对体重从6千克增长到112千克的猪的生长速度、效率、身体组成以及日粮赖氨酸需求的影响。所有猪均来自单一遗传品系且产地相同，通过将猪与环境抗原传播的主要媒介物理隔离和持续暴露来创建低IS猪和高IS猪。在每个IS组中，从七窝仔猪中选取的五只同窝公猪单独圈养，并随机分配到五种日粮氨基酸方案之一（体重6至27千克时赖氨酸含量为0.6%、0.9%、1.20%、1.50%和1.80%，体重27至112千克时赖氨酸含量为0.45%、0.60%、0.75%、0.90%和1.05%）。日粮赖氨酸浓度通过改变日粮中玉米与豆粕的比例来实现，日粮配方使赖氨酸成为第一限制性氨基酸。低IS猪的T淋巴细胞CD4⁺:CD8⁺比值和血清α-1-酰基糖蛋白浓度较低（P < 0.01）。低IS猪还比高IS猪消耗更多（P < 0.01）饲料，体重增长更快（P < 0.01），每单位增重所需饲料更少（P < 0.01），并且在体重112千克时，其身体的肌肉更多（P < 0.12），脂肪组织和内脏更少（P < 0.10）。为了使其蛋白质组织的较高生长能力得以体现，从体重6千克到112千克，每增加14千克体重，低IS猪需要日粮赖氨酸浓度提高0.15至0.30个百分点，每日赖氨酸摄入量增加2至5克。