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老年患者的癌前病变(口腔白斑病和扁平苔藓)

[Precancerous lesions (oral leukoplakia and lichen planus) in the geriatric patient].

作者信息

García-Pola Vallejo M J, García Martín J M, González García M, Telenti Arnáiz P

机构信息

Area Sanitaria de Salud V Gijón (Asturias), Hospital Central de Asturias, Universidad de Oviedo.

出版信息

Aten Primaria. 1997 Jun 15;20(1):41-4.

PMID:9303661
Abstract

OBJECTIVES

To study the prevalence and histopathological behaviour of precancerous lesions of the oral mucous membrane, leukoplakia and lichen planus, among the geriatric population attended.

DESIGN

A prospective, descriptive study.

SETTING

Urban out-patient clinic and health centre in Health Area V in Asturias (population covered: 80,000).

PATIENTS

All patients over 65 in whom one of the lesions under study was observed.

MAIN MEASUREMENTS

All the patients had a complete oral examination. A clinical history was taken for those patients in whom a lesion under study was found, and a sample of the lesion by an incisional or excisional biopsy was taken. Later there were periodic checks and new biopsies were taken.

RESULTS

During the study period, approximately 52,000 mouth and teeth examinations took place. 34 precancerous lesions were detected in patients over 65. The commonest type of lesion was Lichen planus with 20 cases.

CONCLUSIONS

The prevalence found in the sample analysed was similar to that of other studies. The fact that the majority of the lesions had not been noticed clinically, along with the greater susceptibility of these patients to the activation of factors which could trigger malignant degeneration, may have made the presence of 7 lesions with dysplastic histological alterations possible.

摘要

目的

研究在老年就诊人群中口腔黏膜癌前病变(白斑和扁平苔藓)的患病率及组织病理学表现。

设计

一项前瞻性描述性研究。

地点

阿斯图里亚斯卫生区V的城市门诊和健康中心(覆盖人口:80,000)。

患者

所有65岁以上且观察到研究中的一种病变的患者。

主要测量指标

所有患者均接受全面口腔检查。对发现有研究中病变的患者采集临床病史,并通过切取活检或切除活检获取病变样本。之后进行定期检查并再次采集活检样本。

结果

在研究期间,共进行了约52,000次口腔和牙齿检查。在65岁以上患者中检测到34例癌前病变。最常见的病变类型是扁平苔藓,共20例。

结论

分析样本中的患病率与其他研究相似。大多数病变在临床上未被注意到,以及这些患者对可能引发恶性变的因素激活的易感性增加,可能使得出现7例具有发育异常组织学改变的病变成为可能。

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