[橄榄霉素对不同年龄家兔实验性动脉粥样硬化自然消退的影响]
[The effect of olivomycin on the spontaneous regression of experimental atherosclerosis in rabbits of different ages].
作者信息
Frol'kis V V, Novikova S M, Bohats'ka L N, Potapenko R I, Mozzhukhina T H, Kul'chyts'kyĭ O K, Burchyns'ka M K, Kopylova H V
出版信息
Fiziol Zh (1994). 1997;43(3-4):3-10.
Development and regression of experimental atherosclerosis in rabbits is an expressed age-related phenomenon, showing the increase in occurrence and pronouncement of atherosclerotic process with age. A new approach to the disease treatment by means of olivomycin is described. It has shown that while influencing considerably the protein biosynthesis of experimental animal, one can accelerate the regression of atherosclerosis by means of olivomycin and reduce protein and lipid metabolism indicators characterizing the disease development.
家兔实验性动脉粥样硬化的发展与消退是一种明显的年龄相关现象，表现为动脉粥样硬化过程的发生率和严重程度随年龄增加。本文描述了一种用橄榄霉素治疗该疾病的新方法。结果表明，在显著影响实验动物蛋白质生物合成的同时，通过橄榄霉素可以加速动脉粥样硬化的消退，并降低表征疾病发展的蛋白质和脂质代谢指标。
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