de la Llata-Romero M, Cancino C, Cuan V, López-Santibáñez J, Silvia Oropeza E, Ariza-Andraca H
División de Estudios de Posgrado e Investigación, Facultad de Medicina, Ciudad Universitaria, UNAM, México, D.F.
Gac Med Mex. 1997 May-Jun;133(3):175-80; discussion 181.
We prospectively studied the fibrinogen plasma levels of patients with acute myocardial infarction (AMI) and unstable angina (UA) whose diagnosis was based on clinical, electrocardiographical, enzymatic or pirophosphate scintigraphy data. Forty patients were included, 21 with AMI and 19 with UA, each group as well as both were compared to 10 normal individuals. The AMI group consisted of 15 male and 6 female with ages ranging from 35 to 69 years (mean 56.4); the UA group included 15 male and 4 female with an range from 38 to 69 (mean 53.1); the control group was made up 4 male and 6 female with an age range from 28 to 62 years (mean 52.3). All patients had plasma determination of fibrinogen, protrombin time, partial tromboplastin time, platelet count, cholesterol and risk factor for coronary artery disease were obtained on admission. There were no significant differences in regard to platelet count or coagulation times. Fibrinogen was elevated (> 450 mg/ dL) in 27 patients: 15 with AMI: 9 with UA and 3 normal individuals. The comparison of plasma fibrinogen levels between the control group and AMI patients was 397 +/- 131 vs 695 +/- 174, respectively (p < 0.001). Comparison between control group and the UA patients was 397 +/- 131 vs 455 +/- 108, respectively (p = 0.19 NS), and the comparison between the control group and AMI and UA patients gives 397 +/- 131 vs 534 +/- 164 (p < 0.001): Elevated fibrinogen seems to be a contributing factor for coronary artery disease and seems to be a risk factor with as much weight as any other.
我们前瞻性地研究了急性心肌梗死（AMI）和不稳定型心绞痛（UA）患者的血浆纤维蛋白原水平，这些患者的诊断基于临床、心电图、酶学或焦磷酸盐闪烁扫描数据。共纳入40例患者，其中21例为AMI患者，19例为UA患者，将每组患者以及两组患者合并后与10名正常个体进行比较。AMI组包括15名男性和6名女性，年龄在35至69岁之间（平均56.4岁）；UA组包括15名男性和4名女性，年龄在38至69岁之间（平均53.1岁）；对照组由4名男性和6名女性组成，年龄在28至62岁之间（平均52.3岁）。所有患者入院时均测定了血浆纤维蛋白原、凝血酶原时间、部分凝血活酶时间、血小板计数、胆固醇，并获取了冠状动脉疾病的危险因素。血小板计数或凝血时间方面无显著差异。27例患者纤维蛋白原升高（>450mg/dL）：15例AMI患者、9例UA患者和3名正常个体。对照组与AMI患者血浆纤维蛋白原水平的比较分别为397±131和695±174（p<0.001）。对照组与UA患者的比较分别为397±131和455±108（p=0.19，无统计学意义），对照组与AMI和UA患者合并组的比较为397±131和534±164（p<0.001）：纤维蛋白原升高似乎是冠状动脉疾病的一个促成因素，似乎是一个与其他因素权重相当的危险因素。
