[哺乳动物个体发育中的X染色体失活]
[X-chromosome inactivation in mammalian ontogeny].
作者信息
Evdokimova V N, Nazarenko S A
出版信息
Ontogenez. 1997 Jul-Aug;28(4):245-61.
PMID:9304089
Abstract
This review is dedicated to a very interesting problem of developmental genetics: dose compensation of the X-chromosome genes in somatic cells of female mammals. A sequence of events related to X-chromosome inactivation during cell differentiation at the early embryonic stages, association of distributed X-chromosome heterochromatization with developmental pathologies, evolutionary origin of X-inactivation, and its relationship with genomic imprinting are considered.
摘要
本综述致力于发育遗传学中一个非常有趣的问题
雌性哺乳动物体细胞中X染色体基因的剂量补偿。文中考虑了早期胚胎阶段细胞分化过程中与X染色体失活相关的一系列事件、分散的X染色体异染色质化与发育病理学的关联、X染色体失活的进化起源及其与基因组印记的关系。
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