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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Institute of Pharmacy, University of Regensburg, Germany.

Gen Pharmacol. 1996 Dec;27(8):1325-35. doi: 10.1016/s0306-3623(96)00075-4.

Antipsoriatic anthrones are among the most commonly used topical agents for the treatment of psoriasis. 2. These drugs generate reactive oxygen species during their auto-oxidation under physiological conditions. 3. Recent studies have indicated that activation of molecular oxygen by anthrones may play a critical role in their mechanism of action at the molecular level. 4. This article summarizes the evidence pointing toward the significance of oxygen activation and radical formation in the antipsoriatic action and induction of skin inflammation of anthrones. 5. Also, the role of oxygen radical formation in the development of novel anthrones devoid of inflammatory and staining properties is discussed.

抗银屑病蒽酮类药物是治疗银屑病最常用的外用药物之一。2. 这些药物在生理条件下自动氧化过程中会产生活性氧。3. 最近的研究表明，蒽酮类药物对分子氧的激活可能在其分子水平的作用机制中起关键作用。4. 本文总结了表明氧激活和自由基形成在蒽酮类药物抗银屑病作用及诱导皮肤炎症中的重要性的证据。5. 此外，还讨论了氧自由基形成在开发无炎症和染色特性的新型蒽酮类药物中的作用。

Institute of Pharmacy, University of Regensburg, Germany.

Gen Pharmacol. 1996 Dec;27(8):1325-35. doi: 10.1016/s0306-3623(96)00075-4.

Antipsoriatic anthrones are among the most commonly used topical agents for the treatment of psoriasis. 2. These drugs generate reactive oxygen species during their auto-oxidation under physiological conditions. 3. Recent studies have indicated that activation of molecular oxygen by anthrones may play a critical role in their mechanism of action at the molecular level. 4. This article summarizes the evidence pointing toward the significance of oxygen activation and radical formation in the antipsoriatic action and induction of skin inflammation of anthrones. 5. Also, the role of oxygen radical formation in the development of novel anthrones devoid of inflammatory and staining properties is discussed.

抗银屑病蒽酮类药物是治疗银屑病最常用的外用药物之一。2. 这些药物在生理条件下自动氧化过程中会产生活性氧。3. 最近的研究表明，蒽酮类药物对分子氧的激活可能在其分子水平的作用机制中起关键作用。4. 本文总结了表明氧激活和自由基形成在蒽酮类药物抗银屑病作用及诱导皮肤炎症中的重要性的证据。5. 此外，还讨论了氧自由基形成在开发无炎症和染色特性的新型蒽酮类药物中的作用。