RU 41740（生物刺激素）在体外刺激人支气管上皮细胞产生粒细胞巨噬细胞集落刺激因子和白细胞介素-8。

RU 41740 (Biostim) stimulates the production of granulocyte macrophage colony-stimulating factor and interleukin-8 by human bronchial epithelial cells in vitro.

Aloui R, Gormand F, Guibert B, Corallo F, Perrin Fayolle M, Pacheco Y

Service de Pneumologie, Centre Hospitalier Lyon-Sud, Pierre Bénite, France.

Gen Pharmacol. 1996 Dec;27(8):1351-3. doi: 10.1016/s0306-3623(96)00086-9.

Abstract

In this study, we observed the effects of RU 41740 (Biostim) on the production of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-8 (IL-8) in human bronchial epithelial cells in vitro. 2. Cytokine production was assessed by enzyme-linked immunosorbent assay. 3. We report that epithelial cells spontaneously released both cytokines and that RU 41740 induced a significant increase in production of IL-8 and GM-CSF. 4. This is the first observation of a stimulatory effect of an immunostimulating compound used in humans on cytokine production by epithelial cells.

摘要

在本研究中，我们观察了RU 41740（生物刺激素）对体外培养的人支气管上皮细胞中粒细胞-巨噬细胞集落刺激因子（GM-CSF）和白细胞介素-8（IL-8）产生的影响。2. 通过酶联免疫吸附测定法评估细胞因子的产生。3. 我们报告上皮细胞自发释放这两种细胞因子，并且RU 41740可诱导IL-8和GM-CSF的产生显著增加。4. 这是首次观察到用于人类的免疫刺激化合物对上皮细胞产生细胞因子具有刺激作用。