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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Maruyama K, Fukutomi J, Chiba T, Yamaguchi M, Takeda M, Hattori K, Nagatomo T

Department of Pharmacology, Niigata College of Pharmacy, Japan.

Gen Pharmacol. 1996 Dec;27(8):1377-81. doi: 10.1016/s0306-3623(96)00071-7.

We showed that there were two distinct alpha(1)-adrenoceptor subtypes (alpha(1H) and alpha(IL)) in the human prostate which show different affinities for 3H-prazosin. 2. WB4101, tamsulosin, 5-methylurapizil, phentolamin, and terazosin, but not nifedipine, had significantly higher pKi values for the alpha(1H)-subtype than for the alpha(IL)-subtypes. 3. There was good correlation (r = 0.92, P < 0.05) between the pKi values obtained for the alpha(1H)-receptors in membrane fractions and the cloned human alpha(1c)-adrenoceptor subtype.

Maruyama K, Fukutomi J, Chiba T, Yamaguchi M, Takeda M, Hattori K, Nagatomo T

Department of Pharmacology, Niigata College of Pharmacy, Japan.

Gen Pharmacol. 1996 Dec;27(8):1377-81. doi: 10.1016/s0306-3623(96)00071-7.

We showed that there were two distinct alpha(1)-adrenoceptor subtypes (alpha(1H) and alpha(IL)) in the human prostate which show different affinities for 3H-prazosin. 2. WB4101, tamsulosin, 5-methylurapizil, phentolamin, and terazosin, but not nifedipine, had significantly higher pKi values for the alpha(1H)-subtype than for the alpha(IL)-subtypes. 3. There was good correlation (r = 0.92, P < 0.05) between the pKi values obtained for the alpha(1H)-receptors in membrane fractions and the cloned human alpha(1c)-adrenoceptor subtype.