Segawa Y, Shirao Y, Kawasaki K
Department of Ophthalmology, Kanazawa University School of Medicine, Japan.
Jpn J Ophthalmol. 1997 Jul-Aug;41(4):231-4. doi: 10.1016/s0021-5155(97)00049-x.
The mechanisms of the bicarbonate-induced decrease in the ocular standing potential (bicarbonate response) were investigated in the cat. An intravenous infusion of 1.4% sodium bicarbonate solution caused a decrease in the standing potential. A high-bicarbonate solution decreased or increased the potential across the retinal pigment epithelium-choroid tissue of the excised cat eye when applied basally or apically, respectively, but did not affect the potential across the anterior portion of the excised eye or across the isolated neural retina. A high-bicarbonate solution principally depolarized the apical membrane of the retinal pigment epithelium (RPE) when applied basally, and hyperpolarized it when applied apically. These results suggest that the bicarbonate response in the cat is primarily due to the effects of an increase in bicarbonate concentration on the basal membrane of the RPE.
在猫身上研究了碳酸氢盐引起眼静息电位降低的机制（碳酸氢盐反应）。静脉输注1.4%的碳酸氢钠溶液会导致静息电位降低。高碳酸氢盐溶液分别从基底或顶端施加时，会降低或增加离体猫眼视网膜色素上皮-脉络膜组织的电位，但不影响离体眼前部或离体神经视网膜的电位。高碳酸氢盐溶液从基底施加时主要使视网膜色素上皮（RPE）的顶端膜去极化，从顶端施加时则使其超极化。这些结果表明，猫的碳酸氢盐反应主要是由于碳酸氢盐浓度增加对RPE基底膜的影响。
